Rashes (also known as cutaneous lesions) may present in different forms. 

The most well known in SLE is the "butterfly" or malar rash seen on the cheeks. 

Subacute Cutaneous Lupus Erythematosus (SCLE) also involves photosensitive rashes. These can occur on any sun-exposed area and may get worse or better, but are generally non-scarring. They are probably caused by antibody mediated cell death. 

Discoid Lupus - discoid lesions are long lasting and often scarring. Discoid lesions on the scalp are a cause of permanent hair loss. They are also photosensitive but are probably caused by different mechanisms than those in SLE and SCLE (T cell - mediated cell death is the likely cause). 

 Photosensitivity - this is an abnormal reaction to sunlight. About 60% of patients suffer from it. The most common reaction is rashes but sunlight may also exacerbate systemic effects (e.g. Arthritis) resulting in a flare. UVA and UVB light causes damage to everyone's skin resulting in ageing and an increased risk of skin cancer. The effects in lupus are probably brought about through the damage to the cells' DNA which then acts as an antigen, inducing an autoimmune response.

 see the LFA page on photosensitivity. 

Last Updated 5-7-99